| Name | Atpenin A5 |
| Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1]. |
| In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
| In vivo | Atpenin A5, a potent succinate dehydrogenase (SDH) inhibitor, promotes cardiomyocyte mitosis and regeneration in the postnatal heart following myocardial infarction (MI). Mice injected with Atpenin A5 (100 μg/kg) showed increased myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (10.92 mM), Sonication is recommended.
DMSO : 100 mg/mL (273.04 mM), Sonication is recommended.
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| Keywords | sensitive | reperfusion | preconditioning | PotassiumChannel | Potassium Channel | potassium | mKATP | mitochondrial | KcsA | ischemia | Inhibitor | inhibit | complex II | channel | cardioprotective | Atpenin A-5 | Atpenin A5 | Atpenin A 5 | ATP |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | Chlorzoxazone | 2,2,2-Trichloroethanol | Taurocholic acid sodium salt hydrate | Indapamide |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Microbial Natural Product Library | Inhibitor Library | Neuroprotective Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
United States
