| Name | AUDA |
| Description | AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively) |
| Cell Research | Cell Line:Vascular smooth muscle cell (VSMC).Concentration:0.3, 1, 3, 10 μg/mL. Incubation Time:48 hours[1] |
| Animal Research | AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type). C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g).Dosage:10 mg/kg.Administration:i.p.; 14 days[2] |
| In vitro | AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation.?However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs.?On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs.?Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA?) production were required for the enhanced migration[1]. |
| In vivo | AUDA increased the proliferation, migration, adhesion and tube formation ability of HCAECs in a dose-dependent manner.?Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (76.42 mM), Sonication is recommended.
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| Keywords | VSMC | soluble | sEH | Inhibitor | inhibit | hydrolase | EpoxideHydrolase | Epoxide Hydrolase | epoxide | AUDA | anti-inflammatory | activity |
| Inhibitors Related | 1,3-Diphenylurea | Valpromide | VU534 | PAL-4 | N,N'-Dicyclohexylurea | Diflapolin | (Rac)-EC5026 | CAY10640 | sEH inhibitor-3 | GSK2256294A | Dual FAAH/sEH-IN-1 | 1,3-Dibenzylurea |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
