| Name | Aurantiamide acetate |
| Description | Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2]. |
| In vitro | Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively. |
| In vivo | Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2.5 mg/mL (5.62 mM), Sonication is recommended.
DMSO : 55 mg/mL (123.73 mM), Sonication is recommended.
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| Keywords | Piper aurantiacum | Inhibitor | inhibit | inflammatory diseases | CysteineProtease | Cysteine Protease | cathepsin L | Cathepsin B | Cathepsin | Aurantiamide acetate | Aurantiamide | Antifection | adjuvant-arthritic |
| Inhibitors Related | Papain | 2-Aminoethanethiol | (S)-(+)-Ibuprofen | Asperphenamate | PMSF | JNJ-10311795 | N-Ethylmaleimide | Z-Lys-OH | Esomeprazole | 2-Cyanopyrimidine | Aloxistatin | 4-Methylesculetin |
| Related Compound Libraries | Marine Natural Product Library | Bioactive Compound Library | Rare Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Tobacco Monomer Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
