| Name | Ayanin |
| Description | Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches. |
| In vitro | Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 3.3 mg/mL (9.58 mM), Sonication is recommended.
DMSO : 245 mg/mL (711.55 mM), Sonication is recommended.
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| Keywords | tracheal relaxant | respiratory disease | Phosphodiesterase (PDE) | PDE4 | PDE2A | PARP | P450 | Inhibitor | inhibit | ILReceptor | IL Receptor | hypertension | Ayanin | allergic asthma | airway hyperresponsiveness |
| Inhibitors Related | Oxadiazon | Musk ketone | Balipodect | D(+)-Raffinose pentahydrate | Ipriflavone | Benzyl alcohol | Sudan IV | Indomethacin | Naringin | Diallyl disulfide | Dibenzothiophene | Sildenafil citrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
United States
