| Name | AZ7550 hydrochloride |
| Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
| In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1.5 mg/mL (2.87 mM), Sonication and heating are recommended.
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| Keywords | Txk | TEC | PYK2 | MNK2 | MLK1 | IRR | Ins R | Inhibitor | inhibit | IGF-1R | IGF1R | HER1 | FLT4 | FLT3 | FES | FAK | ErbB4 | ErbB-1 | Epidermal growth factor receptor | EGFR | Drug Metabolite | BTK | BRK | BLK | AZ-7550 Hydrochloride | AZ7550 hydrochloride | AZ-7550 | AZ7550 | AZ 7550 Hydrochloride | AZ 7550 | ALK | ACK1 | 1421373-99-0 free base | 1421373-99-0 |
| Inhibitors Related | H-ASP-PHE-OH | 2-(Methylamino)benzoic acid | Melamine | Mycophenolate Mofetil | Ornithine-α-ketoglutarate | 10-Undecen-1-ol | Sorbic acid | Erlotinib | Isonicotinic acid | L-Cysteine hydrochloride hydrate | Gefitinib | Lansoprazole sulfide |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |