AZD-0156 NEW

$2.00 100kg

$4.00 10kg

$6.00 1kg

Min. Order1kg
Purity99%
Cas No1821428-35-6
Supply Ability100kg
Update time2025-10-13

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

VIP1Y

China

Chemical Properties

Product Name	AZD-0156
CAS No	1821428-35-6
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2025/10/13

PRODUCT INFORMA

Common Name	AZD-0156
CAS Number	1821428-35-6	Molecular Weight	461.556
Density	1.2±0.1 g/cm3	Boiling Point	628.3±55.0 °C at 760 mmHg
Molecular Formula	C26H31N5O3	Melting Point	N/A
MSDS	N/A	Flash Point	333.8±31.5 °C

Purity		Quantity		Budget		Inquiry

Use of AZD-0156

AZD0156 is an oral, potent and selective ATM inhibitor with an IC50 of 0.58 nM.

Properties
Spectrum

Name	8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
Synonym	More Synonyms

Description	AZD0156 is an oral, potent and selective ATM inhibitor with an IC50 of 0.58 nM.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR Research Areas >> Cancer
Target	ATM
In Vitro	AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1].
Cell Assay	HT29 cells are seeded into 384 well assay plates at a density of 6000 cells/well in 40 μL EMEM medium containing 1% L glutamine and 10% FBS and allowed to adhere overnight. The following morning compound of Formula (I) in 100% DMSO is added to assay plates by acoustic dispensing. After lh incubation at 37°C and 5% C02, 40 nL of 3 mM 4NQO in 100% DMSO is added to all wells by acoustic dispensing, except minimum control wells which are left untreated with 4NQO to generate a null response control. Plates are returned to the incubator for a further lh. Then cells are fixed by adding 20 μL of 3.7% formaldehyde in PBS solution and incubating for 20 mins at r.t.. Then 20 μL of 0.1% Triton XI 00 in PBS is added and incubated for 10 minutes at r.t., to permeabalise cells. Then the plates are washed once with 50 μL/well PBS, using a Biotek EL405 plate washer.
References	[1]. Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer.?

Density	1.2±0.1 g/cm3
Boiling Point	628.3±55.0 °C at 760 mmHg
Molecular Formula	C26H31N5O3
Molecular Weight	461.556
Flash Point	333.8±31.5 °C
Exact Mass	461.242676
LogP	2.40
Appearance of Characters	white solid
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.626
Storage condition	-20℃

8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]chinolin-2-on

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

8-{6-[3-(Diméthylamino)propoxy]-3-pyridinyl}-3-méthyl-1-(tétrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinoléin-2-one

AZD-0156

AZD0156

Company Profile

Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.

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