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ChemicalBook Product Catalog AZD 9272

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AZD 9272 NEW

$59.00 5mg

$95.00 10mg

$213.00 25mg

Min. Order
Purity98.29%
Cas No327056-26-8
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP4Y

United States

United States

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Chemical Properties

Product Name	AZD 9272
CAS No	327056-26-8
EC-No
Min. Order
Purity	98.29%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	AZD 9272
Description	AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.
In vitro	AZD9272 (10 μM) does not diminish the response to 10 μM ATP in the background GHEK cells. Increasing concentrations of AZD9272 causes a decrease in the potency and the maximal response of DHPG.[1] AZD9272 completely reverses the glutamate-stimulated (EC80=80 μM) phosphatidyl inositol hydrolysis in human mGluR5-GHEK cells in a concentration-dependent manner, with IC50 of 26±3 nM (n=21).[1]
In vivo	AZD 9272 (3 μmol/kg; single intravenous) is eliminated from plasma with terminal half-lives between 2 and 6 h. The terminal half-lives following oral dosing are similar to the half-lives following intravenous dosing. The volume of distribution at steady state is intermediate for AZD9272.[1] AZD9272 (2.84 mg/kg) causes greater than 80% and typically more than 99% MTEP-appropriate responding up to 20 hours after dose, with a decline to approximately 20% at 24 hours after dose, yielding a t1/2 of 21.93 hours, and causes no systematic effects on response rates. The first-time point at which AZD9272 causes >90% MTEP-appropriate response is at 30 minutes after the dose.[2]
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : < 1 mg/mL (insoluble or slightly soluble)
Keywords	mGluR5 \| AZD-9272 \| AZD9272 \| AZD 9272
Inhibitors Related	S-Sulfo-L-cysteine sodium salt \| IDRA-21 \| Urethane \| Decanoic Acid \| DCB \| L-Cysteic acid monohydrate \| Evans blue \| L-Glutamine \| Direct Blue 1 \| L-Glutamic acid monosodium salt \| Memantine hydrochloride \| O-Phospho-L-serine
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Glutamine Metabolism Compound Library \| Neurotransmitter Receptor Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Clinical Compound Library \| Bioactive Compounds Library Max \| Fluorochemical Library

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