| Name | Azvudine |
| Description | Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). |
| In vitro | Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 245 mg/mL (855.98 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.49 mM), Sonication is recommended. H2O : 50 mg/mL (174.69 mM), Sonication is recommended.
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| Keywords | RO0622 | RO 0622 | ReverseTranscriptase | Reverse Transcriptase | resistant | NRTI | mutation | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV-2 | HIV-1 | HIV Protease | HIV | Hepatitis C virus | Hepatitis B virus | HCVProtease | HCV Protease | HCV | HBV | Azvudine | analogue |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Methyl 2-amino-5-bromobenzoate | Dimethyl fumarate | Sofosbuvir | Lamivudine | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Nicotinamide |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library | Nucleotide Compound Library |