| Name | BAM 15 |
| Description | BAM 15 is an uncoupler of mitochondrial protonophore. |
| In vitro | BAM 15 effectively enhances mitochondrial respiration and oxygen consumption across a wide concentration range without increasing reactive oxygen species (ROS), displaying a broader range of action compared to FCCP in myoblasts and hepatocytes. Despite structural differences from FCCP, BAM 15 at concentrations between 100 nM and 1 μM increases the cellular oxygen consumption rate (OCR) similarly to FCCP, but at higher concentrations (1 μM to 50 μM), it sustains uncoupled respiration more effectively across various cell lines. Additionally, BAM 15 causes mitochondrial swelling, indicating its role as a protonophore, and demonstrates greater cell viability than FCCP when used up to 50 μM[1]. |
| In vivo | Animals that receive BAM 15 are protected from kidney injury compared to vehicle-treated mice, such as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 63.75 mg/mL (187.34 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.88 mM), Sonication is recommended.
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| Keywords | oxidative phosphorylation (OXPHOS) | MitochondrialMetabolism | Mitochondrial Metabolism | Inhibitor | inhibit | BAM-15 | BAM15 | BAM 15 |
| Inhibitors Related | Ciprofloxacin hydrochloride monohydrate | Phenoxyethanol | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Ciprofloxacin monohydrochloride | (-)-Epigallocatechin Gallate | Phosphocreatine disodium | Sodium Molybdate | 4-Pentenoic acid | 4'-Hydroxychalcone | L-Histidine |
| Related Compound Libraries | Apoptosis Compound Library | Cuproptosis Compound Library | Glycometabolism Compound Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
United States
