| Name | BAY 2416964 |
| Description | BAY 2416964 is a small molecule inhibitor that selectively targets aromatic receptor (AhR) with an IC50 of 341 nM and is commonly used in cancer immunotherapy research. |
| In vitro | METHODS: Human monocytes were treated with BAY 2416964 (1 nM-10 µM), kynurenic acid (200 µM), and LPS (10 ng/mL) for 24 h, and TNF-α levels were measured by ELISA.
RESULTS: kynurenic acid-induced AhR activation inhibited TNF-α production in LPS-stimulated monocytes, and BAY 2416964 dose-dependently rescued this AhR-mediated inhibition. [1] |
| In vivo | METHODS: To assay antitumor activity in vivo, BAY 2416964 (30 mg/kg) was administered orally to NSG mice bearing B16F10-OVA tumors once daily for seven days.
RESULTS: BAY 2416964 inhibited tumor growth.BAY 2416964 increased the frequency of immunostimulatory tumor-infiltrating CD8+ T cells and N cells, and decreased the frequency of immunosuppressive GR1-positive myeloid cells and CD206+M2 macrophages. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 64.4 mg/mL (166.06 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | CYP1A1 | BAY-2416964 | BAY2416964 | BAY 2416964 | ArylHydrocarbonReceptor | Aryl hydrocarbon receptor | anti-cancer | AhR |
| Inhibitors Related | Diosmin | Sudan IV | 2-Mercaptobenzothiazole | 5,6-Benzoflavone | Benzyl butyl phthalate | 1-Hydroxypyrene | Skatole | L-Kynurenine | Indole-3-carbinol | MeBIO | DiMNF | Dibenzothiophene |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library | Transcription Factor-Targeted Compound Library |
United States
