| Name | BD-AcAc 2 |
| Description | BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson's disease. |
| In vivo | BD-AcAc(2) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1, and CA3 regions of the hippocampus, and the amygdala [2]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 96 mg/mL (544.8 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (28.38 mM), Sonication is recommended.
H2O : 30 mg/mL (170.25 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Parkinson's disease | nutritional ketones | muscle weakness | Ketone | Inhibitor | inhibit | exercise performance | endurance | diabetes | blood glucose | BD-AcAc 2 | BDAcAc 2 | BD AcAc 2 | (R,R)-Ketone Ester |
| Inhibitors Related | Ethoxyquin | Cysteamine hydrochloride | Acetylcysteine | L-Ascorbic acid | Dimethyl fumarate | Glucosamine | D-(+)-Glucono-1,5-lactone | L-Cystine | (-)-Epigallocatechin Gallate | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Arecoline |
| Related Compound Libraries | Cuproptosis Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Ovarian Cancer Compound Library | Anti-Breast Cancer Compound Library | Pyroptosis Compound Library | Mitochondria-Targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library |
United States
