Benazepril Enantiomer HCl NEW

Product Number: B015001
English Name: Benazepril Enantiomer HCl
English Alias: ent-Benazepril 131064-75-0(free base); 2-((R)-3-(((R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid hydrochloride
CAS Number: 215447-89-5
Molecular Formula: C24H28N2O5.HCl 
Molecular Weight:  460.95

Benazepril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of cardiovascular diseases such as hypertension and congestive heart failure. Its mechanism of action is to inhibit ACE, reduce the production of angiotensin II, thereby dilating blood vessels, reducing blood pressure, and improving heart function. Benazepril Enantiomer HCl, as the enantiomer of Benazepril, is of great significance in drug research and development and quality control. The presence of enantiomers may affect the pharmacological activity, pharmacokinetic properties, and safety of the drug, so in-depth research on it is necessary.

In terms of the current research status, the research on Benazepril Enantiomer HCl mainly focuses on the following aspects. In the field of pharmaceutical analysis, researchers are committed to developing highly sensitive and selective analytical methods, such as high-performance liquid chromatography (HPLC) chiral separation technology and capillary electrophoresis chiral separation technology, to accurately separate and determine the content of Benazepril Enantiomer HCl in drugs, ensuring the quality and safety of drugs. In pharmacological research, through animal experiments and in vitro cell experiments, the pharmacological activity and mechanism of action of Benazepril Enantiomer HCl are explored, its differences from Benazepril are compared, and its metabolic pathways and potential adverse reactions in the body are clarified. In addition, in terms of drug synthesis, research on how to reduce or control the generation of Benazepril Enantiomer HCl by improving the synthesis process, and improve the optical purity of Benazepril, thereby optimizing the quality and efficacy of the drug. In clinical research, although Benazepril Enantiomer HCl exists as an impurity, it is also exploring its potential impact on patients who take the drug for a long time, providing a more comprehensive basis for rational clinical medication.