| Name | Betaine chloride |
| Description | Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the formation of secondary structure in GC-rich regions. |
| In vitro | Exposure to increasing levels of Betaine hydrochloride significantly inhibits HeLa cell proliferation, as demonstrated by the MTT assay (p<0.05). The S phase cell percentage is notably higher in groups exposed to doses below 5 mg/mL compared to those subjected to higher doses, whereas Sub-G1 phase rates exhibit the reverse trend (p<0.05). Concentrations of Betaine hydrochloride above 5.0 mg/mL markedly induce apoptosis in HeLa cells (p<0.01). Superoxide dismutase (SOD) activity in low dose groups slightly exceeds that of the control group (p<0.05). Additionally, there's a noticeable synchrony and correlation in the expression levels of pro-apoptotic genes (Bax, P53, Caspase 3) and the anti-apoptotic gene (Bcl-2). Furthermore, upon inducing apoptosis signals, p53 and cyclin D1 are activated, potentially halting the cell cycle at either the G1/S or S/G2 checkpoints. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 43 mg/mL (279.93 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Glycine betaine-binding periplasmic protein | EndogenousMetabolite | Endogenous Metabolite | Circadian clock protein KaiB | Chloridechannel | Chloride channel | Betaine Hydrochloride | Betaine chloride | Betaine |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library |
United States
