| Name | Bisabolangelone |
| Description | Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling. |
| In vitro | Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2].
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| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25 mg/mL (100.68 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.05 mM), Sonication is recommended.
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| Keywords | TNF-α | p38MAPK | p38 MAPK | MAPK | Inhibitor | inhibit | IL Receptor | Bisabolangelone |
| Inhibitors Related | Undecane | Esculin | Bisphenol A | Fumaric acid | Bakuchiol | Skatole | SB 202190 | Afatinib | Phosphocreatine disodium | FERULIC ACID METHYL ESTER | Sodium new houttuyfonate | (Rac)-Hesperetin |
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