| Name | Bis(maltolato)oxovanadium(IV) |
| Description | Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive, and orally active pan-PTP (protein tyrosine phosphatases) inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitizer and has been shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ, and SHP2 with IC50s of 126 nM, 109 nM, 26 nM, and 201 nM, respectively [1][2]. |
| Animal Research | BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
| In vitro | BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells[1]. |
| In vivo | BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 13 mg/mL (40.99 mM), Sonication is recommended.
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| Keywords | uptake | type-2 | SHP-2 | SHP2 | SHP-1 | PTP1B | PTP | Phosphatase | phenotype | metabolic | insulin | Inhibitor | inhibit | HPTPβ | HPTPß | HCPTPA | glucose | diabetes | Bis(maltolato)oxovanadium(IV) | Bis(maltolato)oxovanadium |
| Inhibitors Related | β-Glycerophosphate disodium salt pentahydrate | Hexane-1,6-diol | 2-[dodecyl(2-hydroxyethyl)amino]ethanol | Idoxuridine | Cyclosporine | Tartaric acid disodium dihydrate | Stearic acid | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | L-Ascorbic acid 2-phosphate | β-Glycerophosphate disodium salt hydrate |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max |
United States
