| Name | BIX-01294 |
| Description | BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
| Cell Research | On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1] |
| In vitro | BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1]. |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 84.17 mg/mL (171.55 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.73 mM), Sonication is recommended.
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| Keywords | SUV39H1(H320R) | recurrent | PRMT1 | p53 | p21 | MLKL | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | H3K9me3 | H3K9me2 | Gadd45a | G9a | Cdkn1a | BIX-01294 | BIX01294 | BIX 01294 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Histone Modification Compound Library | Methylation Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Autophagy Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |