| Name | Bixin |
| Description | Bixin is an orally active carotenoid that modulates TLR4/NF-κB, Nrf2, and ROS to mitigate high-fat diet-induced cardiac injury in mice and induces apoptosis in A549, HeLa, and MCF-7 cells. |
| In vitro | Bixin (20-80 μM, 24 hours) not only ameliorated LPS-induced cellular fibrosis in H9C2 cells without cytotoxicity, but also alleviated inflammatory responses by inactivating the TLR4/NF-κB pathway and suppressed LPS-mediated ROS generation through activating the Nrf2 pathway [1].
Bixin (0-500 μM, 48 hours) exhibited anti-proliferative effects on three tumor cell lines: Human lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) [2]. |
| In vivo | Bixin (50-200 mg/kg, orally administered once daily for 14 weeks) alleviates systemic inflammatory responses in a high-fat diet-induced mouse model by inhibiting the activation of the TLR4/NF-κB signaling pathway and reducing pro-inflammatory cytokine secretion. It also decreases ROS production through activation of the Nrf2 pathway while effectively ameliorating systemic metabolic disorder in mice [1]. |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.50 mg/mL (13.94 mM), Sonication is recommended.
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| Keywords | ROS generation | Bixin |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Urea | Tamoxifen | Hydroxychloroquine | Metronidazole | Ethyl linoleate | Formamide | Alginic acid |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
