| Name | BMS 299897 |
| Description | BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for inhibiting Aβ production in HEK293 cells stably overexpressing amyloid precursor protein (APP). |
| In vitro | BMS-299897 (1 μM) decreases these peptides to levels ranging from 20 to 50% of the vehicle control. Furthermore, it leads to a reduction in the proportion of QD-BDNF signals moving in the retrograde direction (p=0.0198) while concurrently increasing the proportion of signals moving in the anterograde direction (p=0.0147).[2] |
| In vivo | BMS-299897 (0.1-1 nmol/mouse; male Swiss mice; one week) blocks the increase in Aβ1-42 content and decreases Aβ1-40 levels significantly. The compound does not affect the Aβ25-35-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocks the Aβ25-35-induced deficits in spontaneous alternation or novel object recognition, using a 1 h intertrial time interval. The co-administration of the γ-secretase inhibitor BMS-299897, in the 0.1-1 μmol/mouse dose range, completely blocks the Aβ25-35-induced increase in Aβ1-42 content.[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 27 mg/mL (52.74 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.91 mM), Sonication is recommended.
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| Keywords | γ-secretase | βAmyloid | β Amyloid | Gammasecretase | BMS-299897 | BMS299897 | BMS 299897 | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Aβ |
| Inhibitors Related | Benzenesulfonamide | Deferoxamine Mesylate | HEPPS | Phytic acid sodium salt | Rutin | Resveratrol | Valproic Acid | 10-Undecenoic acid | 2,4-Di-tert-butylphenol | Chlorzoxazone | Prednisone acetate | Methyl tridecanoate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Protease Inhibitor Library | Multi-Target Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
United States
