| Name | BOC-D-FMK |
| Description | Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM). |
| In vitro | Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2]. |
| In vivo | Boc-D-FMK-fmk significantly reduces apoptosis in hepatocytes of bile duct-ligated rats, potentially enhancing survival rates following endotoxin exposure [3]. A single injection of Boc-D-FMK offers prolonged protection, exceeding 8 weeks, against root avulsion-induced death in motor neurons (MNs), enabling these treated MNs to regenerate axons into an implanted peripheral nerve (PN) graft and successfully reinnervate the target muscle [4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (569.78 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (15.19 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Caspase | BOC-D-FMK | BOCDFMK | BOC D FMK | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Pyroptosis Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Fluorochemical Library | Anti-Cancer Compound Library | Human Metabolite Library |