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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid NEW

$0.00 1kg

$0.00 25kg

Min. Order1kg
Purity98% up by HPLC
Cas No486460-00-8
Supply Ability20tons
Update time2026-04-14

Sinoway Industrial co., ltd.

VIP5Y

China

Since:1996-07-16

Address:16F,HUICHENG COMM,839 XIAHE ROAD,XIAMEN CHINA

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Chemical Properties

Product Name	Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
CAS No	486460-00-8
EC-No	691-120-8
Min. Order	1kg
Purity	98% up by HPLC
Supply Ability	20tons
Release date	2026/04/14

Product Information

Product name	Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Sitagliptin intermediate
CAS No.	486460-00-8
Molecular Formula	C15H18F3NO4
Molecular Weight	333.307
Quality Standard	98% up by HPLC
Appearance	White to off-white powder

COA of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

ITEMS	SPECIFICATION	RESULT
Appearance	White to off-white powder	Conforms
Water content by KF	≤ 0.50%	0.12%
Identity	IR: Conforms to spectrum of the standard	Conforms
Identity	HPLC Conforms to retention time of the standard	Conforms
Specific rotation	+13.0^。~ +18.0^。	+13.6^。
Stereochemical purity by HPLC -S-isomer	≤ 0.10%	0.01%
Related substances by HPLC	3-amino-4-(2,4,5-trifluorophenyl)butanoic acid ≤ 0.10%	0.06%
	Largest unknown impurity ≤ 0.30%	0.05%
	Total impurities ≤ 0.50%	0.11%
Solvent residue by GC	Ethyl acetate ≤ 500ppm	74 ppm
	Heptane ≤ 500ppm	78 ppm
	Methanol ≤ 300ppm	35 ppm
	Toluene ≤ 89ppm	ND
	Acetonitrile ≤ 41ppm	ND
Residue on ignition	≤ 0.50%	0.04%
Metal residue Rh	≤ 10ppm	< 10ppm
Assay(By Anhydrous base)	98.0～102.0%	100.1%

Usage

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is one of key intermediates of Sitagliptin.

Physical properties of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid:

(1)ACD/LogP: 2.341;

(2)# of Rule of 5 Violations: 0;

(3)ACD/LogD (pH 5.5): 0.98;

(4)ACD/LogD (pH 7.4): -0.78;

(5)ACD/BCF (pH 5.5): 1.55;

(6)ACD/BCF (pH 7.4): 1.00;

(7)ACD/KOC (pH 5.5): 19.59;

(8)ACD/KOC (pH 7.4): 1.00;

(9)#H bond acceptors: 5;

(10)#H bond donors: 2;

(11)#Freely Rotating Bonds: 7;

(12)Index of Refraction: 1.494;

(13)Molar Refractivity: 75.072 cm³;

(14)Molar Volume: 257.776 cm³;

(15)Surface Tension: 40.6020011901855 dyne/cm;

(16)Density: 1.293 g/cm³;

(17)Flash Point: 221.754 °C;

(18)Enthalpy of Vaporization: 73.842 kJ/mol;

(19)Boiling Point: 443.058 °C at 760 mmHg;

(20)Vapour Pressure: 0 mmHg at 25°C.

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Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.