| Name | Bradykinin (2-9) |
| Description | Bradykinin (2-9) (Des-Arg1-bradykinin) is an amino-truncated peptide compound that is a metabolite of Bradykinin. It is formed by the cleavage action of Aminopeptidase P. |
| In vitro | The Bradykinin peptide system, crucial for cardiovascular and renal functions, is examined using a highly sensitive amino terminal-directed radioimmunoassay combined with high-performance liquid chromatography. This method allows for the precise measurement of various Bradykinin peptides, including Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9). An additional carboxy terminal-directed radioimmunoassay facilitates the characterization of these peptides in rat kidney and blood. The primary findings indicate that Bradykinin-(1-9) and Bradykinin-(1-7) are the most abundant in the kidney, with significantly lower concentrations of Bradykinin-(1-8) and Bradykinin-(4-9), while Bradykinin-(2-9) and Bradykinin-(3-9) are undetectable. Blood analysis shows very low levels of Bradykinin-(1-9), with other peptides falling below detection thresholds. Administration of the ACE inhibitor Perindopril significantly increases renal levels of Bradykinin-(1-8) and Bradykinin-(1-9), altering the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. This radioimmunoassay approach is also effectively applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain tissues, identifying similar abundance levels of Bradykinin-(1-7) and Bradykinin-(1-9), with Bradykinin-(1-8) present in lower amounts. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mM, Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (2.21 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | BradykininReceptor | Bradykinin Receptor | Bradykinin (2-9) | Bradykinin (29) | Bradykinin (2 9) | Bradykinin |
| Inhibitors Related | Safotibant | NPC 567 acetate | [Des-Arg9]-Bradykinin acetate | Icatibant Acetate | B-Raf IN 14 | Anatibant 2HCl | (Hyp³)-Bradykinin acetate | MK-0686 | Zoliprofen | 5-Hydroxy-1-methylhydantoin | Sar-[D-Phe8]-des-Arg9-Bradykinin acetate | Lys-[Des-Arg9]Bradykinin acetate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
