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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Metabolism Carbonic Anhydrase Inhibitors Brinzolamide

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Brinzolamide NEW

$30.00 10mg

$58.00 25mg

$89.00 50mg

Min. Order
Purity99.84%
Cas No138890-62-7
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	Brinzolamide
CAS No	138890-62-7
EC-No
Min. Order
Purity	99.84%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Brinzolamide
Description	Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. Its mechanism of action involves inhibiting the enzyme Carbonic Anhydrase.
In vitro	A 0.6 mg dose of Brinzolamide ophthalmic suspension reduces intraocular pressure in a dose-dependent manner in cynomolgus monkeys post-laser glaucoma surgery. Similarly, it lowers intraocular pressure in Dutch belted rabbits. Dosages of 1 mg/kg, 10 mg/kg, and 30 mg/kg of Brinzolamide prolong the sleep time induced by barbital in male CD-1 mice by 57%, 15%, and 35%, respectively. Less than 3% of Brinzolamide significantly increases both the percentage reduction and the mean decrease in intraocular pressure among patients with primary open-angle glaucoma or ocular hypertension compared to a placebo group. Additionally, a 2% Brinzolamide solution enhances optic nerve head blood flow and reduces intraocular pressure in resting Dutch belted rabbits.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (156.45 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.21 mM), Sonication is recommended.
Keywords	IOP \| intraocular pressure \| Inhibitor \| inhibit \| glaucoma \| CarbonicAnhydrase \| Carbonic anhydrase II \| Carbonic Anhydrase \| Carbonate dehydratase \| Brinzolamide \| atrial fluid \| AL4862 \| AL 4862
Inhibitors Related	Benzenesulfonamide \| Urea \| Sodium Dihydrogen Phosphate \| Cyclamic acid sodium \| Hydrochlorothiazide \| Orthanilamide \| Zonisamide \| Tioxolone \| 2-Methoxy-4-propylphenol \| pNNP \| Fluorometholone Acetate \| Acesulfame
Related Compound Libraries	Bioactive Compound Library \| Approved Drug Library \| ReFRAME Related Library \| EMA Approved Drug Library \| Anti-Cancer Metabolism Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Cardiovascular Disease Compound Library \| FDA-Approved Drug Library \| Metabolism Compound Library \| Bioactive Compounds Library Max \| Anti-Hypertension Compound Library

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