| Name | BSH-IN-1 |
| Description | BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH). |
| In vitro | BSH-IN-1 also inhibits BSH activity in growing cultures of Gram-negative (Bacteroides fragilis ATCC 25285, B. theta VPI-5482, and Bacteroides vulgatus ATCC 8482) and Gram-positive (C. perfringens ATCC 13124, Lactobacillus plantarum WCFS1, and Bifidobacterium adolescentis L2–32) bacteria. BSH-IN-1 also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis and B. theta, respectively. |
| In vivo | In C57BL/6 mice, BSH-IN-1 (10 mg/kg; a single dose; gavage）inhibits BSH activity and can be gut-restricted. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (97.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.89 mM), Sonication is recommended.
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| Keywords | PotassiumChannel | Potassium Channel | BSH-IN-1 | BSHIN1 | BSH IN 1 | Bile salt hydrolase (BSH) |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Potassium Channel Targeted Library | Covalent Inhibitor Library | Ion Channel Targeted Library | Anti-Infection Compound Library | Anti-Cancer Compound Library |
United States
