| Name | Bupivacaine hydrochloride |
| Description | Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation. |
| In vitro | Bupivacaine can induce calcium release from the sarcoplasmic reticulum (SR) in rats and suppress the SR's uptake of calcium. |
| In vivo | In vitro, Bupivacaine exhibits cytotoxic effects on bovine articular chondrocytes after an exposure of 15 to 30 minutes. It acts on isolated mitochondria as an uncoupler of oxygen consumption and adenosine diphosphate phosphorylation. Concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation are induced by Bupivacaine in these isolated mitochondria. Additionally, Bupivacaine triggers the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel pivotal in various forms of cell death. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.16 mM), Sonication is recommended.
DMSO : 16.67 mg/mL (51.31 mM), Sonication is recommended.
H2O : 21 mg/mL (64.64 mM), Sonication is recommended.
Ethanol : 60 mg/mL (184.68 mM), Sonication is recommended.
|
| Keywords | SodiumChannel | Sodium Channel | Potassium Channel | pain | NMDA | Na+ channels | Na channels | local | KcsA | Ionotropic glutamate receptors | Inhibitor | inhibit | iGluR | electrophysiology | channel | Calcium Channel | Ca2+ channels | Ca channels | Bupivacaine hydrochloride | Bupivacaine | anesthetics |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Phenytoin sodium | L-Ascorbic acid | Decanoic Acid | L-Glutamic acid | 1,8-Cineole | Valproic Acid | Indole-2-carboxylic acid | L-Ascorbic acid sodium salt | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
