| Name | Butin |
| Description | Butin, the major bioactive flavonoid isolated from Dalbergia odorifera heartwood, possesses oral activity with notable antioxidant, antiplatelet, and anti-inflammatory effects. This compound effectively alleviates myocardial infarction, improves cardiac function, and prevents diabetes-induced cardiac oxidative damage in rats. |
| In vitro | Methods: H9c2 cells were treated with Butin (12.5, 25, 50 μM, 6 hours). Cell viability was detected by MTT assay, target protein expression was detected by Western blotting, and target gene expression was detected by real-time qPCR.
Results: Butin increased cell survival in a dose-dependent manner, increased the expression of GSH-px, GSH, SOD, CAT, and HO-1, and increased the level of Nrf2 in the cytoplasm and nucleus in a dose-dependent manner, and enhanced the expression of GSH-px, GSH, SOD, CAT, and HO-1. [1] |
| In vivo | Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rats [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.12 mM), Sonication is recommended.
DMSO : 80 mg/mL (293.85 mM), Sonication is recommended.
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| Keywords | Butin |
| Inhibitors Related | Thiamine monochloride | Maltol | Butylated hydroxytoluene | AFMK | DL-alpha-Tocopherylacetate | Neohesperidin | Sulbutiamine | L-Cystine | γ-Terpinene | Tyrosol | 4-hydroxyphenylacetic acid | Trolox |
| Related Compound Libraries | Flavonoid Natural Product Library | Bioactive Compound Library | Antioxidant Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
