| Name | Butoconazole nitrate |
| Description | Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms. |
| In vivo | Dexpanthenol has positive effects on protection of cerebral tissue after ischaemia reperfusion[1]. Topical application of dexpanthenol is widely used in clinical practice for the improvement of wound healing. Upregulation of IL-6, IL-1, CYP1B1, CXCL1, CCL18 and KAP 4-2 gene expression and downregulation of psorasin mRNA and protein expression are identified in samples treated topically with dexpanthenol[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 250 mg/mL (526.55 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.95 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | RS-35887 | RS35887 | progestogenReceptor | progestogen Receptor | Inhibitor | inhibit | Fungal | EstrogenReceptor | Estrogen Receptor | ER | Butoconazole Nitrate | Butoconazole |
| Inhibitors Related | Calcium Propionate | Dehydroacetic acid sodium | Potassium gluconate | Tamoxifen | D-Gluconic acid (solution) (50% in H2O) | Sulfacetamide sodium | Benzyl propionate | Terbinafine hydrochloride | Sodium formate | Magnesium acetate tetrahydrate | Geraniol | L-Citronellol |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bitter Compound library | Bioactive Compounds Library Max | Anti-Infection Compound Library | NMPA-Approved Drug Library | Human Metabolite Library |
United States
