Cabergoline

Description: Cabergoline is an ergot alkaloid derivative and a dopamine receptor agonist with similar effects to bromocriptine. It is characterized by being potent, long-lasting and selective, and has a high affinity for D2 dopamine receptors. It also has a strong and lasting inhibitory effect on mammary gland secretion. This product is easily absorbed, with a peak blood concentration of 1 to 3 hours, a plasma protein binding rate of 40%, and a half-chemical book life of 63 to 100 hours. This product is extensively metabolized by hydrolysis and is mainly excreted through bile and feces. It is mainly used for Parkinson's disease, Parkinson's syndrome, and hyperprolactinemia. This product can reduce the severity of the "switch phenomenon" caused by long-term use of levodopa, significantly increase the time in the "on" state, and reduce the amount of levodopa required by 18%.