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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Microbiology Integrase Inhibitors Cabotegravir

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Cabotegravir NEW

$46.00 10mg

$89.00 25mg

$158.00 50mg

Min. Order
Purity99.92%
Cas No1051375-10-0
Supply Ability10g
Update time2026-04-12

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Cabotegravir
CAS No	1051375-10-0
EC-No
Min. Order
Purity	99.92%
Supply Ability	10g
Release date	2026/04/12

Product Introduction

Bioactivity

Name	Cabotegravir
Description	Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Kinase Assay	In vitro strand transfer assay: The inhibitory concentrations of GSK1265744 is measured in a strand transfer assay using recombinant HIV IN. A complex of integrase and biotinylated donor DNA–streptavidin-coated SPA beads is formed by incubating 2 μM purified recombinant integrase with 0.66 μM biotinylated donor DNA–4 mg/mL streptavidin-coated SPA beads in 25 mM sodium MOPS pH 7.2, 23 mM NaCl, and 10 mM MgCl2 for 5 minutes at 37°C. These beads are spun down and preincubated with diluted INSTIs for 60 minutes at 37°C. Next, [3H]-labeled target DNA substrate is added to give a final concentration of 7 nM substrate, and the strand transfer reaction is incubated at 37°C for 25 to 45 minutes, which allowed for a linear increase in strand transfer of donor DNA to radiolabeled target DNA. The signal is read using a Wallac MicroBeta scintillation plate reader.
In vivo	GSK1265744 (50 mg/kg) effectively prevents high-dose SHIV infection in rhesus macaques.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 16.67 mg/mL (41.12 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
Keywords	UGT1A1 \| S/GSK-1265744 \| S/GSK 1265744 \| OAT \| Inhibitor \| inhibit \| Human immunodeficiency virus \| HIVProtease \| HIV Protease \| HIV Integrase \| HIV \| GSK-744 \| GSK1265744 \| GSK 744 \| GSK 1265744 \| Cabotegravir \| antiretroviral \| AIDS
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Emtricitabine \| Dolutegravir intermediate-1 \| Dimethyl fumarate \| Lamivudine \| Chloroquine phosphate \| Valproic Acid \| (-)-Epigallocatechin Gallate \| Decanedioic acid \| Dextran sulfate sodium salt (MW 5000) \| Tenofovir
Related Compound Libraries	Bioactive Compound Library \| Pediatric Drug Library \| Drug-induced Liver Injury (DILI) Compound Library \| ReFRAME Related Library \| EMA Approved Drug Library \| Anti-Viral Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| FDA-Approved Drug Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Anti-Infection Compound Library

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