| Name | Caffeic Acid |
| Description | Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels. |
| In vitro | METHODS: Human A549 cells were treated with Caffeic Acid for 48 h, and cell growth inhibition was measured using MTT assay.
RESULTS: Caffeic Acid inhibited the growth of A549 cells (IC50=0.7 mM). [1]
METHODS: Human AGS and HCT-116 cells were treated with Caffeic Acid for 96 hours, and cell growth inhibition was detected using MTT assay.
RESULTS: Caffeic Acid inhibited the growth of AGS (IC50=129 μM) and HCT-116 (IC50=29.73 μM) cells. [2] |
| In vivo | METHODS: To study the anti-pruritus effect of Caffeic Acid, Caffeic Acid (500 mg/kg) was orally administered to mice induced by histamine and chloroquine.
RESULTS: Caffeic acid pretreated mice showed significantly less histamine-induced scratching and chloroquine-induced scratching. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (27.75 mM), Sonication is recommended.
DMSO : 250 mg/mL (1387.66 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRP Channel | Transient receptor potential channels | LOX | Lipoxygenase | Inhibitor | inhibit | hTRPA1 | EndogenousMetabolite | Endogenous Metabolite | Caffeic Acid | 5-Lipoxygenase |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Bitter Compound library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
