| Name | CAIX Inhibitor S4 |
| Description | CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM. |
| In vitro | CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1]. |
| In vivo | CAIX Inhibitor S4 (10 mg/kg; i.p.) reduces lung metastasis in the orthotopic MDA-MB-231 mouse model without impacting primary tumor growth[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 245 mg/mL (730.51 mM), Sonication is recommended.
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| Keywords | XII | tumor | S-4 | S 4 | orthotopic | metastasis | lung | Inhibitor | inhibit | CAXII | CarbonicAnhydrase | Carbonic anhydrase IX | Carbonic anhydrase II | Carbonic anhydrase I | Carbonic Anhydrase | Carbonate dehydratase | CAIX Inhibitor S-4 | CAIX Inhibitor S4 | CAIX Inhibitor S 4 |
| Inhibitors Related | Benzenesulfonamide | Urea | Sodium Dihydrogen Phosphate | Cyclamic acid sodium | Hydrochlorothiazide | Orthanilamide | Zonisamide | Tioxolone | 2-Methoxy-4-propylphenol | pNNP | Fluorometholone Acetate | Acesulfame |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Multi-Target Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |