| Name | Calcifediol |
| Description | Calcifediol (U 32070E) is a naturally occurring product that is metabolized in the liver from vitamin D3, a VDR ligand. Calcifediol is indicated for use as a vitamin supplement for all patients with vitamin D deficiency. |
| In vitro | Calcifediol, whether in liposomes or ethanolic solution, does not affect the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. However, treating infected human bronchial 16-HBE cells with Calcifediol liposomes significantly reduces bacterial survival [1]. |
| In vivo | METHODS: Calcifediol (25 µg/kg) was administered dietary to rats for four weeks to study its role in pregnancy.
RESULTS: Calcifediol provided better vitamin D availability to the mother and fetus when administered during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcome were observed, and further studies are needed to investigate the effects of Calcifediol on fetal brain VDR and GAD67 expression. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (249.6 mM), Sonication is recommended.
Ethanol : 16 mg/mL (39.94 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.98 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Vitamin D receptor | Vitamin D | Vitamin | VD/VDR | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Calcifediol |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Natural Product Library | Inhibitor Library | FDA-Approved Drug Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Human Metabolite Library |
United States
