Description of Calcium folinate（Leucovorin Calcium） from Watson Biotechnology Co., Ltd
Basic Information of Calcium folinate（Leucovorin Calcium） |
Product Name | Calcium folinate（Leucovorin Calcium） |
CAS NO. | 1492-18-8 |
Apperance | White powder |
Assay | 99% |
Pacakge | 1kg/Foil Bag,25kg/Drum/Box |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Watson |
Specifications(COA) of Calcium folinate （Leucovorin Calcium） CAS 1492-18-8
ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White or light yellow ,amorphous or crystalline,hygroscopie powder | Conform |
Identification | 1) IR absorption spectrophotometry 2) Test for Calcium 3) The retention time of the Leucovorin Calcium peak of the sample solution corresponds to that of the standard solution as obtained in the assay. | Conform |
Solubility | Sparingly soluble in water,practically insoluble in acetone and in ethanol (96%) | Conform |
Water | ≤ 17.0% | 14.95% |
Individual unspecified impurity | ≤0.3% | Conform |
Total impurities | ≤2.5 | Conform |
Limit of 56-(Y-Folinoyl)Tetrahydrofolate | ≤ 0.3% | Conform |
Residual solvents | Ethanol ≤0.3% | Conform |
Microbial | Total aerobic microbial count ≤1000cfu/g | Conform |
Total molds and yeast count: ≤100cfu/g |
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Assay % | 95.0 ～105.0 | 99.4 |
Conclusion | Confirm to USP43. |
Calcium folinate, also known as leucovorin, is a medication with several important medical applications:
1. Chemotherapy Rescue: It's primarily used to reduce the toxic effects of methotrexate, a chemotherapy drug. Methotrexate inhibits the enzyme dihydrofolate reductase, which is necessary for DNA synthesis. Calcium folinate "rescues" normal cells by providing a source of folate, allowing them to continue DNA synthesis, thereby mitigating the harmful effects of methotrexate.
2. Enhancement of Chemotherapy: In some cases, calcium folinate is used to enhance the effects of chemotherapy drugs like 5-fluorouracil (5-FU). It stabilizes the binding of 5-FU to the enzyme thymidylate synthase, increasing its effectiveness against cancer cells.
3. Treatment of Folic Acid Deficiency: Calcium folinate is also used to treat or prevent folic acid deficiency when normal folic acid supplementation is inadequate, such as in certain types of anemia.
4. Overdose of Folate Antagonists: It is used as an antidote for overdoses of folate antagonists, like methotrexate, or in cases where there is an increased risk of toxicity from these drugs.
5. Pernicious Anemia: It may be used in combination with other medications for the treatment of pernicious anemia, although it’s not the primary treatment.
These applications make calcium folinate a versatile and critical drug in both oncology and other medical fields.
FAQ From Watson Biotechnology Co., Ltd |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
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Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
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Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
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Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
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Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
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Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance.
With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy.
At Watson Biotechnology, we pride ourselves on our cutting-edge facilities and state-of-the-art technology, which enable us to deliver superior products that cater to a diverse range of needs across various sectors. Our dedication to continuous improvement and customer satisfaction drives us to maintain stringent quality control processes and foster an environment of innovation and growth.
Watson Biotechnology Co., Ltd is a professional manufacturer which provide Calcium folinate（Leucovorin Calcium）with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Calcium folinate（Leucovorin Calcium）.
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