| Name | Canertinib dihydrochloride |
| Description | Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. |
| Kinase Assay | Kinase inhibition: Cediranib is dissolved in DMSO at a concentration of 10 mM. All enzyme assays are run at, or just below, the respective Km for ATP (0.2 - 30 μM). The inhibitory activity of Cediranib is determined against a range of recombinant tyrosine kinases [KDR, Flt-1, Flt-4, c-Kit, PDGFRα, PDGFRβ, CSF-1R, Flt-3, FGFR1, Src, Abl, epidermal growth factor receptor (EGFR), ErbB2, Aurora A, and Aurora B] using ELISA. Selectivity versus CDK2 and CDK4 serine/threonine kinases is examined using scintillation proximity assays with a retinoblastoma substrate and [γ-sup>33P]ATP. Activity of Cediranib is compared to MAPK kinase (MEK), which shows dual specificity. It is determined using a MAPK substrate, [γ-33P]ATP, and paper capture/scintillation counting. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.58 mM), Sonication is recommended. DMSO : 59.38 mg/mL (106.25 mM), Sonication is recommended.
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| Keywords | PD183805 Dihydrochloride | PD-183805 | PD183805 | PD 183805 Dihydrochloride | PD 183805 | HER2/ErbB2 | EGFR | CI1033 Dihydrochloride | CI-1033 | CI1033 | CI 1033 Dihydrochloride | CI 1033 |
| Inhibitors Related | Rifampicin | Phenytoin sodium | Levofloxacin hydrochloride | Ribavirin | L-Lysine | L-Lysine hydrochloride | Ofloxacin | Vidarabine | Thymidine | N4-Acetylcytidine | Gefitinib | Danthron |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |