| Name | cangrelor tetrasodium |
| Description | Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. |
| In vitro | cangrelor, a non-sepesific GPR17 antagonist, alleviates pulmonary fibrosis partly by inhibiting macrophage inflammation in mice.Cangrelor is also a well-known anti-platelet agent. cangrelor (10 mg/kg) not only significantly decreased BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreased the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice. In addition, cangrelor decreased the number of CD40 and MPO double positive neutrophils and the expression level of CD40 in BLM-treated mouse lungs[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 80 mg/mL (92.56 mM), Sonication is recommended.
DMSO : 12.56 mg/mL (14.53 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.16 mM), Sonication is recommended.
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| Keywords | pulmonary | platelet | P2YReceptor | P2Y Receptor | P2Y | intravenous | Inhibitor | inhibit | inflammation | GPR17 | fibrosis | cangrelor tetrasodium | cangrelor | antiplatelet | aggregation |
| Inhibitors Related | Monomethyl fumarate | Pamoic acid disodium | Azathioprine | CRTh2 antagonist 2 | Fezagepras sodium | (±) Clopidogrel hydrogen sulfate | Uridine-5'-diphosphate disodium salt | Benzyl nicotinate | Uridine triphosphate trisodium salt | TUG-1375 | Ticagrelor | Diquafosol tetrasodium |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
