| Name | Carbimazole |
| Description | Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease. |
| Kinase Assay | In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot. |
| In vivo | Once absorbed by the human body, Carbimazole is metabolized into Methimazole, which exerts anti-thyroid activity. It specifically targets conditions such as hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (thyroid inflammation). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (10.74 mM), Sonication is recommended.
Ethanol : 12 mg/mL (64.44 mM), Sonication is recommended.
DMSO : 60 mg/mL (322.18 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Thyroidhormonereceptor(THR) | Thyroidhormonereceptor | Thyroid peroxidase | Thyroid hormone receptor(THR) | Thyroid hormone receptor | THR | MMI | methimazole | Inhibitor | inhibit | Graves' disease | Carbimazole | antithyroid agent |
| Inhibitors Related | Undecane | Esculin | Bisphenol A | Fumaric acid | Bakuchiol | Octinoxate | Skatole | SB 202190 | (-)-Bornyl acetate | Afatinib | FERULIC ACID METHYL ESTER | (Rac)-Hesperetin |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bitter Compound library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
