| Name | Cefozopran hydrochloride |
| Description | Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin. is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. |
| In vitro | Cefozopran hydrochloride (SCE-2787 hydrochloride), a fourth-generation cephalosporin, exhibits substantial activity against a range of bacteria. Cefozopran hydrochloride is effective against gram-positive organisms, including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci. Additionally, Cefozopran hydrochloride demonstrates efficacy against gram-negative organisms such as Hemophilus influenza. Notably, Cefozopran hydrochloride displays comparatively good activity against enterococci and P. aeruginosa, which are typically resistant to other cephalosporins[2]. |
| In vivo | In four-week-old ICR male mice, Cefozopran hydrochloride, administered subcutaneously at doses ranging from 5 to 80 mg/kg twice a day for 5 days, proves effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In a model of chronic respiratory tract infection induced by K. pneumoniae 27, Cefozopran hydrochloride, at doses between 20 and 80 mg/kg administered subcutaneously twice a day for 7 days in five-week-old CBA/J female mice, exhibits effectiveness comparable to Ceftazidime[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 30 mg/mL (54.35 mM), Sonication is recommended.
DMSO : 30 mg/mL (54.35 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.62 mM), Sonication is recommended.
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| Keywords | SCE-2787 Hydrochloride | SCE2787 Hydrochloride | SCE 2787 Hydrochloride | Fungal | Cefozopran Hydrochloride |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Levulinic acid | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Anti-Fungal Compound Library | Antibiotics Library | Drug Repurposing Compound Library | Beta-Lactam Compound Library | Anti-Bacterial Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Gram-Positive Bacterial Library |
United States
