Ceftazidime-avibactam sodium is a compound antibiotic that combines the third-generation cephalosporin ceftazidime with the β-lactamase inhibitor avibactam. It is mainly used to treat complex intra-abdominal infections, hospital-acquired pneumonia, and infections caused by multi-drug resistant Gram-negative bacteria.
During the quality research of ceftazidime avibactam sodium, the main risk impurities include: polymer impurities (such as dimer and trimer), degradation products (ring-opening, deamidation, oxides), process residues (solvents, metal ions), and potential genotoxic impurities (such as nitrosamines). These impurities may affect the stability, safety and efficacy of the drug, and are frequent concerns in the review and supplementary approval process.
As Guangzhou PI PI Biotech Inc, a manufacturer with 15 years of specialized expertise in impurity research, we are capable of providing a full range of degradation impurities derived from process-related sources, long-term stability samples, accelerated stability samples, and forced degradation studies. We also offer complete structural characterization data, including HPLC, MASS, HNMR, CNMR, 2D-NMR techniques (such as COSY, HSQC, HMBC, and DEPT135), IR, TGA, QNMR, and SER. The product information is as follows:
| Catalog No. | Name |
| 1000980-60-8 | Ceftazidime EP impurity A |
| 102772-66-7 | Ceftazidime EP impurity E |
| 1354396-23-8 | Ceftazidime EP impurity H |
| 194241-83-3 | Ceftazidime EP impurity G |
| 97148-38-4 | Ceftazidime EP impurity B |
| PI00011009 | Ceftazidime Oxide Impurity 2 |
| PI00011010 | (6R,7S)-Ceftazidime |
| PI00011011 | (E)-Ceftazidime Oxide Impurity |
| PI00011012 | Ceftazidime-d5 |
| PI00011013 | Ceftazidime Side Chain Impurity |
| PI00011014 | Ceftazidime Impurity D |
| PI00011015 | Ceftazidime Lactone |
| PI00011016 | Ceftazidime Double Mother Nucleus Impurity |
| PI00011017 | Ceftazidime Oxide Impurity 1 |
| PI00011018 | Acetoxy Ceftazidime Dimer |
| PI00011019 | Acetoxy Ceftazidime Intermediate |
| PI00011020 | Ceftazidine Active Ester Ttrans Impurity |
| PI00011021 | Ceftazidine Dimer A |
| PI00011022 | Ceftazidine Dime B |
| PI00011024 | Ceftazidime impurity K |
| PI00011025 | Ceftazidime impurity 25 |
| PI00011026 | Ceftazidime Active Ester Dimer |
| PI00011027 | Ceftazidime Side Chain Ethyl Ester |
| PI00011029 | Δ3-7-APCA |
| PI00011030 | Ceftazidime Trans Side-Chain Acid |
| PI00011031 | Ceftazidine Dimer C |
| PI00011032 | Ceftazidine Dimer D |
| PI00011033 | Ceftazidine Dimer E |
| PI00011034 | Ceftazidine Trimer A |
| PI00011035 | Ceftazidine Trimer B |
| PI00011036 | Ceftazidime impurity 36 |
| PI00011038 | Ceftazidine Dimer F |
| PI00011039 | Ceftazidine Dimer H |
| PI00011040 | Ceftazidime impurity 40 |
| PI14009001 | Avibactam impurity 1 |
| PI14009002 | Avibactam impurity 2 |
| PI14009003 | Avibactam impurity 3 |
| PI14009004 | Avibactam Methyl sulfonate |
| PI14009005 | Avibactam Ethyl sulfonate |
| PI14009006 | Avibactam Isopropyl sulfonate |
| PI14009007 | Avibatam N-nitroso BPO |
| PI14009008 | Avibatan impurity R |
| PI14009009 | Avibatamine arginine complex 1 |
| PI14009010 | Avibatamine arginine complex 2 |
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