Cefuroxime Sulfoxide
Product Code：C022021
English Name：Cefuroxime Sulfoxide
English Alias：(6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide
CAS No.：[Not Available]
Molecular Formula：C₁₆H₁₆N₄O₉S
Molecular Weight：440.38
High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and circular dichroism for stereostructure, suitable for precise analysis of Cefuroxime sulfoxide impurities.
Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.2% in acetonitrile-water solution within 6 months.
Quality Control Testing：Used for UPLC-MS/MS detection of sulfoxide impurities in Cefuroxime API and formulations, controlling impurity content to meet ICH Q3A standards (≤0.1%).
Process Optimization Research：Monitors Cefuroxime Sulfoxide formed by oxidation side reactions during Cefuroxime synthesis or storage, reducing generation by >60% by adjusting reaction temperature (e.g., 5-10℃) and antioxidant dosage.
Method Validation：Serves as a standard for developing sulfoxide impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).
Cefuroxime, a second-generation cephalosporin antibiotic, may generate Cefuroxime Sulfoxide as an oxidation impurity during production (sulfur atom oxidation) or under storage conditions (e.g., light, high temperature). The sulfoxide structure of this impurity may affect Cefuroxime's antibacterial activity, stability, and safety. With stricter international regulatory requirements for drug impurity control, studying such oxidative degradation impurities is crucial for ensuring Cefuroxime quality.
Detection Technology：UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 3 minutes, with LOD of 0.005 ng/mL for trace analysis.
Formation Mechanism：Formed by oxidation of the sulfur atom in Cefuroxime molecules under the action of oxygen or peroxides; optimizing antioxidant conditions (e.g., nitrogen protection) and purification processes (e.g., cryogenic crystallization) inhibits its formation.
This product is intended for laboratory use only!
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