Cepharanthine

Stephanine is a bipartite isowalin alkaloid isolated from Stephania Stephania and Rhizoma stephaniae. It has the functions of anti-tumor, anti malaria, bacteriostasis and regulating immune function. Modern research suggests that it also has the functions of stimulating reticuloendothelial system, activating hematopoietic tissue and promoting bone marrow tissue proliferation. It has been used to prevent and treat leukopenia caused by radiotherapy, chemotherapy and other reasons in tumor patients. Therefore, stephanine is considered to be a low toxicity and effective leukocyte raising drug. Stephanine can partially reverse the multidrug resistance of leukemia fine chemicalbook cells, and the effect is significantly better than the classical reversal drug verapamil, and the cytotoxic effect is much less than verapamil at the reversal dose. Foreign studies have also shown that stephanine has a good reversal effect on multiple drug-resistant cells. Stephanine can enhance the immune function and activity of cells and macrophages in vivo. In Japan, stephanine has been used clinically as a leukocyte raising drug for more than years without obvious toxic and side effects. It has been used in the experimental treatment of pneumoconiosis for many years in China. The above results suggest that stephanine has great clinical value.