| Name | Cepharanthine |
| Description | Cepharanthine (NSC-623442) is a natural alkaloid that inhibits TNF-α-mediated NFκB stimulation, plasma membrane lipid peroxidation, and platelet aggregation, as well as cytokine production. Cepharanthine exhibits anti-inflammatory, antioxidant, and antitumor activities. |
| In vitro | In a xenograft model using SAOS2 cells in athymic mice, daily treatment with Cepharanthine (20 mg/kg) significantly reduced tumor volume and weight. |
| In vivo | In SaOS2 cells, Cepharanthine (2.5–20 μmol/L) inhibits cell growth in a concentration- and time-dependent manner. At concentrations of 5–10 μmol/L, Cepharanthine markedly suppresses the expression of STAT3 target genes, including the anti-apoptotic gene Bcl-xL and cell cycle regulators c-Myc and cyclin D1. At 10 μmol/L, Cepharanthine induces a cell cycle arrest at the G1 phase and promotes apoptosis in SaOS2 cells. Furthermore, Cepharanthine (10–15 μmol/L) significantly reduces STAT3 expression in SAOS2 cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 9.3 mg/mL (15.33 mM), Solution.
DMSO : 242 mg/mL (398.87 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
|
| Keywords | TNF-α | Stephania?cephalantha?Hayata | SARS-CoV | SARS coronavirus | proliferation | NSC623442 | NSC 623442 | natural product | Inhibitor | inhibit | HIVProtease | HIV Protease | HIV | effective | Cepharanthine | Autophagy | Apoptosis |
| Inhibitors Related | Aceglutamide | Hemin | Emtricitabine | Guanidine hydrochloride | Hydroxychloroquine | Lamivudine | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Formamide | Paeonol | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-Cancer Active Compound Library |
United States
