cefradine (cefradine) is a semi-synthetic cephalosporin antibiotic successfully researched by Squibb Pharmaceutical Company in 1972, belonging to the first generation of cephalosporin, and entered the pharmaceutical market in the 1970s. It is stable to stomach acid and its antibacterial action is similar to cephalexin when administered orally and cephalothiophene when administered by injection. It has killing effect on most gram-positive and gram-negative bacteria, and has good antibacterial effect on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus virescens which do not produce penicillinase and Chemicalbook producing penicillinase, but slightly poor activity against Escherichia coli, Proteus and Klebsiella. It has some effect on Neisseria gonorrhoeae, and also has activity on gonococcus zymogenes, but has poor activity on Haemophilus influenzae. Pseudomonas aeruginosa, drug-resistant enterobacter, Bacteroides fragilis, mycoplasma and chlamydia were resistant to it, and other anaerobic bacteria were sensitive to it.