| Name | CGS 15943 |
| Description | CGS 15943 is an orally bioavailable non-xanthine antagonist of the Adenosine Receptor. In transfected CHO cells, its Ki values for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM, respectively. |
| In vitro | CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ (IC50: 1.1 μM). CGS 15943 shows slight inhibition on p110δ (IC50: 8.47 μM). CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 1 mg/mL (3.5 mM), Sonication is recommended. DMSO : 12.22 mg/mL (42.77 mM), Sonication is recommended.
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| Keywords | PI3K | Phosphoinositide 3-kinase | p110δ | p110γ | P1 receptor | Inhibitor | inhibit | CGS-15943 | CGS15943 | CGS 15943 | AdenosineReceptor | Adenosine Receptor | adenosine A3 receptor | adenosine A2B receptor | adenosine A2A receptor | adenosine A1 receptor | A3 | A2B | A2A | A1 |
| Inhibitors Related | Musk ketone | Theophylline monohydrate | Myricetin | Creatine monohydrate | Hyaluronic acid | 4-Methylbenzylidene camphor | Inosine | Theobromine | Isoprenaline hydrochloride | Methyl eugenol | Quercetin | Doxofylline |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |