| Name | CH-223191 |
| Description | CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection. |
| In vitro | METHODS: HepG2 cells were treated with CH-223191 (0.1-10 μM) for 1 hour, and the protein levels were detected by Western Blot method.
RESULTS: C-223191 reduces the expression of cytochrome P450 1A1 protein caused by TCDD. [1] |
| In vivo | METHODS: To study the preventive toxic effects of CH-223191 on 2,3,7,8-TCDD, CH-223191 (10 mg/kg) was intraperitoneally injected into male ICR mice once a day for 25 consecutive days.
RESULTS: C-223191 inhibited the expression of liver cytochrome P450 1A1 and the intracellular fat content in hepatocytes, and reduced the AST and ALT activities in mice treated with TCDD. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Powder: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 3.3 mg/mL (9.9 mM), Sonication is recommended.
DMSO : 127 mg/mL (380.94 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (3 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | CH-223191 | CH223191 | ArylHydrocarbonReceptor | Aryl Hydrocarbon Receptor | AhR |
| Inhibitors Related | Nimodipine | Diosmin | Sudan IV | 2-Mercaptobenzothiazole | Benzyl butyl phthalate | 1-Hydroxypyrene | Skatole | Tryptamine hydrochloride | L-Kynurenine | Indole-3-carbinol | Leflunomide | Dibenzothiophene |
United States
