| Name | Chelidonic acid |
| Description | Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity. |
| Animal Research | female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge. |
| In vivo | Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reactions induced by ovalbumin in mice by inhibiting caspase-1 activity[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.00 mg/mL (21.73 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.00 mg/mL (5.43 mM), Sonication is recommended.
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| Keywords | r-Pyrone-2,6-dicarboxylic acid | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | gamma-Pyrone-2,6-dicarboxylic acid | Chelidonic acid | Caspase-1 | Caspase |
| Inhibitors Related | Sodium propionate | Kojic acid | Uridine | Fumaric acid | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | Magnesium acetate tetrahydrate | N,N-Dimethylacetamide | Cystamine dihydrochloride | Copper Sulfate Pentahydrate | Magnesium sulfate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
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