| Name | Chlorprothixene |
| Description | Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized. |
| In vitro | When Chlorprothixene acts on the brain, it inhibits the postsynaptic mesolimbic dopamine D1 and D2 receptors, reducing the release of hypothalamic and pituitary hormones. In mouse brains, Chlorprothixene reduces levels of 5HT, NE, and DA. At high doses, Chlorprothixene's effect on adrenal medulla and brain tissue can inhibit the action of nicotinic acid isopropylhydrazine, inducing the release of catecholamines for protective purposes. Additionally, Chlorprothixene has an inhibitory effect on acidic sphingomyelin in murine bronchial epithelial cells, promoting the repair of neuronal myelin concentration, thereby decreasing the incidence of inflammatory responses in mice with cystic fibrosis and also preventing infection by Pseudomonas aeruginosa. |
| In vivo | Chlorprothixene induces Vero 76 cells, resulting in inhibited replication of SARS-CoV. It exhibits high affinity for the murine 5-HT6 receptor in stably transfected HEK-293 cells, with a Ki value of 3 nM, and for the transiently expressed murine 5-HT7 receptor in COS-7 cells, with a Ki value of 5.6 nM. Chlorprothixene has a strong binding affinity to histamine and dopamine receptors including D1, D2, D3, D5, and H1, with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM, and 3.75 nM, respectively. However, its affinity for the H3 receptor is weak, with a Ki value greater than 1000 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 10 mg/mL (31.66 mM), Sonication is recommended.
Ethanol : 27 mg/mL (85.48 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.17 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | H1 receptor | DopamineReceptor | Dopamine Receptor | Dopamine | D3 | D2 | Chlorprothixene | Bacterial | 5HTReceptor | 5-HT7 | 5-HT6 | 5HT Receptor |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Alginic acid | BES |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
