| Name | Ciclopirox olamine |
| Description | Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. |
| Cell Research | Sabouraud glucose medium (2%) is used for cell culture growth, and RPMI 2% glucose medium and 2% Sabouraud glucose medium are used for MIC determinations. For cell culture growth curves, 220 mL of 2% Sabouraud glucose medium containing different concentrations of Ciclopirox are inoculated with 105 cells/mL, and the mixture is shaken at 160 rpm and 37 °C for 1-10 hours. Growth is measured photometrically at 630 nm. FeCl3 or 2,2'-bipyridine is added to the medium at different concentrations for inhibition studie(Only for Reference) |
| In vivo | Ciclopirox exhibits inhibitory effects on the growth of Candida albicans strain SC5314 (MIC80=1.0-2.0μg/mL) and Aspergillus fumigatus strain B5233 (IC50=4.22 μM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 28 mg/mL (104.34 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.73 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 32.33 mg/mL (120.48 mM), Sonication is recommended.
|
| Keywords | iron | Inhibitor | inhibit | HOE-296 | HOE296 | HOE 296 | Fungal | Ferroptosis | Ciclopirox olamine | Ciclopirox | Bacterial | ATPase |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Hemin | Levulinic acid | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Fungal Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
