| Name | Ciliobrevin D |
| Description | Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro. |
| In vitro | Ciliobrevin D reversibly inhibits melanosome aggregation, however, the non-cilia-disrupting derivative had no discernible effect at comparable doses. Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels and it similarly abrogates the movement of peroxisomes in Drosophila S2 cells[1]. |
| In vivo | In the testis in vivo, Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D perturbs spermatogenesis. The use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 9.23 mg/mL (23.51 mM), Sonication and heating to 80℃ are recommended.
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| Keywords | γ-tubulin | spindles | Smoothened | peroxisomes | melanosome | Inhibitor | inhibit | Hedgehog | dynein | Cytoplasmic dynein | cytoplasmic | Ciliobrevin D | ATPases | ATPase | aggregation |
| Inhibitors Related | Itraconazole | Sodium oleate | 5-LOX inhibitor | Permethrin | Tolbutamide | Vismodegib | trans-Aconitic acid | Phlorizin | Chlorpropamide | 2,3-Butanedione 2-Monoxime | Revaprazan hydrochloride | Oleic acid |
| Related Compound Libraries | Osteogenesis Compound Library | Bioactive Compound Library | Cancer Cell Differentiation Compound Library | Membrane Protein-targeted Compound Library | Hematonosis Compound Library | Microtubule-Targeted Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | GPCR Compound Library |
United States
