| Name | Cinanserin hydrochloride |
| Description | Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. |
| In vitro | Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro[1]. |
| In vivo | Cinanserin (5 mg/kg; intravenous injection; 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 125 mg/mL (331.62 mM), Sonication is recommended. H2O : 100 mg/mL (265.29 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (10.61 mM), Sonication is recommended.
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| Keywords | virus | systemic | SQ-10643 | SQ10643 | Serotonin Receptor | replication | proteinase | leukocyte | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | endothelial | edema | Cinanserin hydrochloride | Cinanserin | burn | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT2 Receptor | 5-HT2 | 5-HT Receptor | 5HT Receptor | 3C-like proteinase | 3C-like |
| Inhibitors Related | Alverine citrate | Acetylcysteine | Dapoxetine hydrochloride | Cefaclor monohydrate | Nitazoxanide | 1,8-Cineole | Curcumin | Baicalein | Salcomine | Benzimidazole | β-Cyclodextrin | Cinchonidine |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Angiogenesis related Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library | Serotonin Receptor-Targeted Compound Library |