| Name | Cipepofol |
| Description | Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome. |
| In vitro | Cipepofol (5 μM; administered before ISO injury; for 6 hours) can attenuate ISO-induced apoptosis in cultured cardiomyocytes in vitro[2]. |
| In vivo | In eighty male C57BL/6 mice (20-24 g, 8-10 weeks old), Cipepofol (100 μl; administered into the abdomen of mice 1 hour before ISO injection) was able to attenuate the increase in serum CK-MB, LDH, and cTnT levels induced by ISO (100 mg/kg; subcutaneous injection; for 2 consecutive days) to create experimental myocardial infarction. Additionally, Cipepofol significantly improved ISO-induced left ventricular systolic and diastolic dysfunction[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (391.56 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (16.15 mM), Sonication is recommended.
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| Keywords | GABAReceptor | GABAA | GABA Receptor | Cipepofol | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Nicotinamide riboside malate | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Penicillin G sodium salt | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | Ferroptosis Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Transcription Factor-Targeted Compound Library |
United States
