| Name | Citric acid |
| Description | Citric acid (Citro) is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a food additive and a natural preservative. |
| In vitro | METHODS: HaCaT cells were treated with Citric acid (0-12.5 mM) for 24 hours, and the percentage of viable cells was determined by flow cytometry.
RESULTS: Citric acid exhibited anti-proliferative activity in a dose-dependent manner. [1]
METHODS: HaCaT cells were treated with Citric acid (12.5 mM) for 48 hours, and the levels of related proteins were detected by western blot.
RESULTS: Citric acid increased the expressions of FAS, BAX, BID, AIF, EndoG, cytochrome C, PARP, GADD153, GRP78 and Caspase-3, -8, -9, and decreased the expressions of BCL-2 and BCL-Xl. [1] |
| In vivo | METHODS: To study the effect of Citric acid on the liver of mice, Citric acid (120, 240, and 480 mg/kg) was intraperitoneally injected into mice.
RESULTS: Citric acid significantly reduced the activity of GSH-Px in the liver of mice, induced an increase in the level of MDA (malondialdehyde), and increased the activity of caspase-3 to induce apoptosis in a dose-dependent manner. [2]
METHODS: To study the nephrotoxicity of Citric acid, Citric acid (120, 240, and 480 mg/kg) was intraperitoneally injected into mice every week for 3 consecutive weeks.
RESULTS: Citric acid causes nephrotoxicity in mice. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (520.51 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (26.03 mM), Sonication is recommended.
DMSO : 240 mg/mL (1249.22 mM), Sonication is recommended.
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| Keywords | S phase | renal toxicity | Oxidative damage | MDA levelsm | Inhibitor | inhibit | HaCaT cells | G2/M phase | EndogenousMetabolite | Endogenous Metabolite | Citric acid | Bacterial | Apoptosis | antioxidative | Antibiotic |
| Inhibitors Related | Sucrose | Neomycin sulfate | Aceglutamide | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Gluconate Calcium | Dimethyl sulfoxide | Sodium bicarbonate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Flavor Natural Product library | Cosmetic Ingredient Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
